Human genetics–driven discovery
Large-scale human genetic data integrated with functional genomic, proteomic and clinical datasets identify causal mechanisms in cardiovascular disease and improve risk prediction.
ATHENA Network Collaborative Laboratory
ATHENA Co-Lab
Atherosclerosis Targets from Human gEnetics and functional geNomic Approaches — a shared research platform that enables cardiovascular investigators to identify, prioritize and validate causal genes and mechanisms underlying atherosclerosis.
Functional genomics in human tissues and cells
Genomic and single-cell approaches in relevant human tissues and cell types identify causal genes within CVD-associated loci.
In vivo causal mechanism discovery
Top candidate genes for coronary artery disease and stroke are validated in simplex and multiplex murine models, complemented by ex vivo studies of human tissue.
Collaborate
Ways to work with ATHENA
- Propose a candidate locus or genes for study in ATHENA functional assays
- Submit atherosclerosis candidate genes for ATHENA CRISPR screens
- Access genome-scale ATHENA CRISPR screening data
- Explore vascular gene expression through the interactive ATHENA spatial transcriptomics portal
- Access ATHENA study protocols and single-cell workflows
Other proposals welcome! Contact us.
Investigative team
Organizers
- Thomas Quertermous, MD, MSUS OrganizerProfessor, Stanford University, Stanford, US
- Helle Jørgensen, PhDEuropean OrganizerAssociate Professor, University of Cambridge, UK
- Ljubica Matic, PhDProfessor, Karolinska Institutet, Stockholm, Sweden
- Samuli Ripatti, PhDDirector, FIMM; Professor, University of Helsinki, Finland
- Nathan Stitziel, MD, PhDProfessor, Washington University in St. Louis, US